Computational analysis of luteolin, apigenin and their derivatives from Allophylus africanus as potential inhibitors of plasmepsin II a malaria target

Computational analysis of luteolin, apigenin and their derivatives from Allophylus africanus as potential inhibitors of plasmepsin II a malaria target

Abstract Malaria remains a critical global health challenge, especially in Sub-Saharan Africa, with drug-resistant strains heightening the need for new treatment strategies. Plasmepsin II, a key enzyme in the life cycle of malaria presents a promising target for novel antimalarial drugs. This study...

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Bibliographic Details
Main Authors: Ismail Abubakari, Lucas P. Kwiyukwa, Lucas Paul
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Chemistry
Subjects:
Malaria
Apigenin
Luteolin
Molecular dynamics
Molecular docking
Plasmodium falciparum
Online Access:https://doi.org/10.1186/s13065-025-01527-w
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https://doi.org/10.1186/s13065-025-01527-w

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