Bioengineered hybrid dual-targeting nanoparticles reprogram the tumour microenvironment for deep glioblastoma photodynamic therapy

Bioengineered hybrid dual-targeting nanoparticles reprogram the tumour microenvironment for deep glioblastoma photodynamic therapy

Abstract Glioblastoma (GBM) poses significant therapeutic challenges due to its hypoxic and immunosuppressive tumour microenvironment (TME), low immunogenicity and physical barriers. While combining photodynamic therapy (PDT) with immunotherapy holds promise, its efficacy is hampered by insufficient...

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Main Authors: Rongrong Zhao, Ying Hou, Boyan Li, Ziwen Pan, Jiawei Qiu, Qingtong Wang, Yanhua Qi, Zhe Han, Hongyu Zhao, Hong Liu, Weijia Zhou, Gang Li, Hao Xue
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63081-2
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https://doi.org/10.1038/s41467-025-63081-2

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