Resolvin D1 accelerates resolution of neuroinflammation by inhibiting microglia activation through the BDNF/TrkB signaling pathway

Abstract Background Neuropathic pain is characterized by hyperalgesia, allodynia, and inflammation and it is often resistant to treatment. The formyl peptide receptor 2 (ALX/FPR2), a G-protein-coupled receptor, has been implicated in resolving inflammation, making its agonist, Resolvin D1 (RvD1), a...

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Bibliographic Details
Main Authors: Cunju Bo, Xiaoming Liu, Yongjian Liu, Lingjun Xu, Qiaodong Huang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:European Journal of Medical Research
Subjects:
Online Access:https://doi.org/10.1186/s40001-025-02424-7
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