Pharmacological Inhibition of Endogenous Hydrogen Sulfide Production Slows Bladder Cancer Progression in an Intravesical Murine Model

Pharmacological Inhibition of Endogenous Hydrogen Sulfide Production Slows Bladder Cancer Progression in an Intravesical Murine Model

Present bladder cancer therapies have relatively limited therapeutic impact and account for one of the highest lifetime treatment costs per patient. Therefore, there is an urgent need to explore novel and optimized treatment strategies. The present study investigated the effects of inhibiting endoge...

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Bibliographic Details
Main Authors: Sydney Relouw, George J. Dugbartey, Patrick McLeod, Natasha N. Knier, Francisco Martinez Santiesteban, Paula J. Foster, Heather-Anne Cadieux-Pitre, Nicole M. Hague, Jenna Caine, Kaitlin Belletti, Sally Major, Caroline O’Neil, Manal Y. Gabril, Madeleine Moussa, Melissa J. Huynh, S.M. Mansour Haeryfar, Alp Sener
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Pharmaceuticals
Subjects:
bladder cancer (BC)
gemcitabine
hydrogen sulfide (H<sub>2</sub>S)
intravesical administration
magnetic resonance imaging
propargylglycine (PAG)
Online Access:https://www.mdpi.com/1424-8247/17/9/1212
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https://www.mdpi.com/1424-8247/17/9/1212

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