IMP2 drives chemoresistance by repressing cisplatin-induced apoptosis and ferroptosis via activation of IPO4 and SLC7A11 under hypoxia in bladder cancer

IMP2 drives chemoresistance by repressing cisplatin-induced apoptosis and ferroptosis via activation of IPO4 and SLC7A11 under hypoxia in bladder cancer

Abstract Background Cisplatin resistance is the leading cause of mortality in muscle-invasive bladder cancer (MIBC) cases. Previous evidence suggests that abnormal epitranscriptome modifications are associated with reduced chemotherapy responses. However, the exact underlying mechanism remains large...

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Bibliographic Details
Main Authors: Yilin Yan, Zhengnan Huang, Zhen Zhu, Yang Wang, Xiangqian Cao, Chenkai Yang, Junfeng Jiang, Shujie Xia, Bing Shen
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cancer Cell International
Subjects:
Bladder cancer
Chemoresistance
IMP2
Ferroptosis
DNA damage repair
Online Access:https://doi.org/10.1186/s12935-024-03570-4
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https://doi.org/10.1186/s12935-024-03570-4

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