LncRNA HOXA10-AS as a novel biomarker and therapeutic target in human cancers
Long non-coding RNAs (lncRNAs) are crucial regulatory molecules that participate in numerous cellular development processes, and they have gathered much interest recently. HOXA10 antisense RNA (HOXA10-AS, also known as HOXA-AS4) is a novel lncRNA that was identified to be dysregulated in some preval...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1520498/full |
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| _version_ | 1841561218396979200 |
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| author | Xin Hu Yong Wang Sijia Zhang Xiaosi Gu Xiaoyu Zhang Lianlian Li Lianlian Li |
| author_facet | Xin Hu Yong Wang Sijia Zhang Xiaosi Gu Xiaoyu Zhang Lianlian Li Lianlian Li |
| author_sort | Xin Hu |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) are crucial regulatory molecules that participate in numerous cellular development processes, and they have gathered much interest recently. HOXA10 antisense RNA (HOXA10-AS, also known as HOXA-AS4) is a novel lncRNA that was identified to be dysregulated in some prevalent malignancies. In this review, the clinical significance of HOXA10-AS for the prognosis of various cancers is analyzed. In addition, the major advances in our understanding of the cellular biological functions and mechanisms of HOXA10-AS in different human cancers are summarized. These cancers include esophageal carcinoma (ESCA), gastric cancer (GC), glioma, laryngeal squamous cell carcinoma (LSCC), acute myeloid leukemia (AML), lung adenocarcinoma (LUAD), nasopharyngeal carcinoma (NPC), oral squamous cell carcinoma (OSCC), and pancreatic cancer. We also note that the aberrant expression of HOXA10-AS promotes malignant progression through various underlying mechanisms. In conclusion, HOXA10-AS is expected to serve as an ideal clinical biomarker and an effective cancer therapy target. |
| format | Article |
| id | doaj-art-cd973c7f469443babbb76c7a93800a43 |
| institution | Kabale University |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-cd973c7f469443babbb76c7a93800a432025-01-03T05:10:24ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-01-011110.3389/fmolb.2024.15204981520498LncRNA HOXA10-AS as a novel biomarker and therapeutic target in human cancersXin Hu0Yong Wang1Sijia Zhang2Xiaosi Gu3Xiaoyu Zhang4Lianlian Li5Lianlian Li6Department of Immunology, School of Clinical and Basic Medical Sciences, Shandong First Medical University, Jinan, Shandong, ChinaShandong Provincial Engineering Research Center for Bacterial Oncolysis and Cell Treatment, Jinan, Shandong, ChinaDepartment of Immunology, School of Clinical and Basic Medical Sciences, Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Immunology, School of Clinical and Basic Medical Sciences, Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Immunology, School of Clinical and Basic Medical Sciences, Shandong First Medical University, Jinan, Shandong, ChinaDepartment of Immunology, School of Clinical and Basic Medical Sciences, Shandong First Medical University, Jinan, Shandong, ChinaLaboratory of Metabolism and Gastrointestinal Tumor, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, ChinaLong non-coding RNAs (lncRNAs) are crucial regulatory molecules that participate in numerous cellular development processes, and they have gathered much interest recently. HOXA10 antisense RNA (HOXA10-AS, also known as HOXA-AS4) is a novel lncRNA that was identified to be dysregulated in some prevalent malignancies. In this review, the clinical significance of HOXA10-AS for the prognosis of various cancers is analyzed. In addition, the major advances in our understanding of the cellular biological functions and mechanisms of HOXA10-AS in different human cancers are summarized. These cancers include esophageal carcinoma (ESCA), gastric cancer (GC), glioma, laryngeal squamous cell carcinoma (LSCC), acute myeloid leukemia (AML), lung adenocarcinoma (LUAD), nasopharyngeal carcinoma (NPC), oral squamous cell carcinoma (OSCC), and pancreatic cancer. We also note that the aberrant expression of HOXA10-AS promotes malignant progression through various underlying mechanisms. In conclusion, HOXA10-AS is expected to serve as an ideal clinical biomarker and an effective cancer therapy target.https://www.frontiersin.org/articles/10.3389/fmolb.2024.1520498/fulllong non-coding RNAHOXA10-ASsignaling pathwaybiomarkertherapeutic target |
| spellingShingle | Xin Hu Yong Wang Sijia Zhang Xiaosi Gu Xiaoyu Zhang Lianlian Li Lianlian Li LncRNA HOXA10-AS as a novel biomarker and therapeutic target in human cancers Frontiers in Molecular Biosciences long non-coding RNA HOXA10-AS signaling pathway biomarker therapeutic target |
| title | LncRNA HOXA10-AS as a novel biomarker and therapeutic target in human cancers |
| title_full | LncRNA HOXA10-AS as a novel biomarker and therapeutic target in human cancers |
| title_fullStr | LncRNA HOXA10-AS as a novel biomarker and therapeutic target in human cancers |
| title_full_unstemmed | LncRNA HOXA10-AS as a novel biomarker and therapeutic target in human cancers |
| title_short | LncRNA HOXA10-AS as a novel biomarker and therapeutic target in human cancers |
| title_sort | lncrna hoxa10 as as a novel biomarker and therapeutic target in human cancers |
| topic | long non-coding RNA HOXA10-AS signaling pathway biomarker therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1520498/full |
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