A comprehensive analysis of the tryptophan metabolism-related gene signature to predict the prognosis of esophageal squamous cell carcinoma based on multi-omics

A comprehensive analysis of the tryptophan metabolism-related gene signature to predict the prognosis of esophageal squamous cell carcinoma based on multi-omics

BackgroundTryptophan (Trp) metabolism plays a vital role in tumor development and outcomes. However, Trp in esophageal squamous cell carcinoma (ESCC) remains poorly understood. We aimed to explore the role and mechanism of Trp metabolism in ESCC.MethodsWe integrated single-cell RNA (scRNA) sequencin...

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Bibliographic Details
Main Authors: Zhengjie Wu, Zhiping Liu, Yukun Wang, Geling Teng, Xiaodong Li, Tong Lu, Fangning Hu, Shuo Wu, Guanqiang Ma, Hua Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
tryptophan metabolism
esophageal squamous cell carcinoma
multi-omics
tumor environment
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1613539/full
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https://www.frontiersin.org/articles/10.3389/fmolb.2025.1613539/full

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