In vitro Antitumor Activity and Electrochemical Studies of Bio-Electroactive Anthraquinone Derivatives in Glioblastoma
Abstract This study investigated the antiglioblastoma potential of nine synthetic anthraquinone derivatives (SAQDs). SAQDs were tested for their in vitro cytotoxicity against PBMCs and GBM02 cells. For PBMC, SAQDs showed no cytotoxic effects up to 100 µM. Four most promising SAQDs (1, 4, 5, and 9) d...
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Academia Brasileira de Ciências
2025-06-01
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| author | SUELLEN MARIA A. DA SILVA JOÃO KAYCKE S. DA SILVA JOICE FRAGOSO O. DE ARAÚJO ANDRESSA LETÍCIA L. DA SILVA ANDRESA KATHERINE A. DE ALMEIDA TAMIRES A. DO NASCIMENTO ANDRÉ FELIPPE A. XAVIER RENATA G. DE ALMEIDA GUILHERME AUGUSTI M. JARDIM EUFRÂNIO N. DA SILVA JÚNIOR VIVALDO MOURA-NETO ALYSSON WAGNER F. DUARTE PIERRE BARNABÉ ESCODRO JOÃO XAVIER DE ARAÚJO JÚNIOR MARÍLIA O.F. GOULART ALINE C. DE QUEIROZ MAGNA SUZANA ALEXANDRE-MOREIRA |
| author_facet | SUELLEN MARIA A. DA SILVA JOÃO KAYCKE S. DA SILVA JOICE FRAGOSO O. DE ARAÚJO ANDRESSA LETÍCIA L. DA SILVA ANDRESA KATHERINE A. DE ALMEIDA TAMIRES A. DO NASCIMENTO ANDRÉ FELIPPE A. XAVIER RENATA G. DE ALMEIDA GUILHERME AUGUSTI M. JARDIM EUFRÂNIO N. DA SILVA JÚNIOR VIVALDO MOURA-NETO ALYSSON WAGNER F. DUARTE PIERRE BARNABÉ ESCODRO JOÃO XAVIER DE ARAÚJO JÚNIOR MARÍLIA O.F. GOULART ALINE C. DE QUEIROZ MAGNA SUZANA ALEXANDRE-MOREIRA |
| author_sort | SUELLEN MARIA A. DA SILVA |
| collection | DOAJ |
| description | Abstract This study investigated the antiglioblastoma potential of nine synthetic anthraquinone derivatives (SAQDs). SAQDs were tested for their in vitro cytotoxicity against PBMCs and GBM02 cells. For PBMC, SAQDs showed no cytotoxic effects up to 100 µM. Four most promising SAQDs (1, 4, 5, and 9) demonstrated significant activity against GBM02, with selectivity index >4.54 for 1, >1.30 for 4 and 5, and >1.19 for 9. These compounds induced morphological changes, incluing cell rounding, cytoplasmic vacuolation, and membrane rupture, and inhibited cell migration. Due to the pharmacological role of oxidative stress, electrochemical methods were used to compare the reductive and oxidative capacities of the SAQD with their antitumor activity. Considering the reported findings, it is feasible to confirm that some SAQDs have antitumor effects, supporting additional studies of AQ for developing novel anticancer medications. Due to the small number of compounds investigated, it was not possible to observe a relationship between electrochemical and biological data. However, the electrochemical data are new and could be used to prepare other compounds on this line. CV data revealed that the sulfone’s electron-withdrawing effect facilitated the reduction. At the same time, the sulfides had shown less positive potential for oxidation waves due to the presence of electron-donating groups. |
| format | Article |
| id | doaj-art-cd911e224e1b4a8398833890f2cf117d |
| institution | DOAJ |
| issn | 1678-2690 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj-art-cd911e224e1b4a8398833890f2cf117d2025-08-20T02:39:32ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902025-06-0197310.1590/0001-3765202520241466In vitro Antitumor Activity and Electrochemical Studies of Bio-Electroactive Anthraquinone Derivatives in GlioblastomaSUELLEN MARIA A. DA SILVAhttps://orcid.org/0000-0003-1944-9513JOÃO KAYCKE S. DA SILVAhttps://orcid.org/0000-0002-5962-7858JOICE FRAGOSO O. DE ARAÚJOhttps://orcid.org/0000-0002-8478-1531ANDRESSA LETÍCIA L. DA SILVAhttps://orcid.org/0000-0002-0952-7613ANDRESA KATHERINE A. DE ALMEIDAhttps://orcid.org/0000-0001-9520-7394TAMIRES A. DO NASCIMENTOhttps://orcid.org/0000-0001-9726-8107ANDRÉ FELIPPE A. XAVIERhttps://orcid.org/0009-0000-7387-6001RENATA G. DE ALMEIDAhttps://orcid.org/0000-0003-2896-0487GUILHERME AUGUSTI M. JARDIMhttps://orcid.org/0000-0002-9882-3085EUFRÂNIO N. DA SILVA JÚNIORhttps://orcid.org/0000-0003-1281-5453VIVALDO MOURA-NETOhttps://orcid.org/0000-0002-6266-043XALYSSON WAGNER F. DUARTEhttps://orcid.org/0000-0001-9626-7524PIERRE BARNABÉ ESCODROhttps://orcid.org/0000-0002-9409-660XJOÃO XAVIER DE ARAÚJO JÚNIORhttps://orcid.org/0000-0003-3187-183XMARÍLIA O.F. GOULARThttps://orcid.org/0000-0001-9860-3667ALINE C. DE QUEIROZhttps://orcid.org/0000-0002-6362-2726MAGNA SUZANA ALEXANDRE-MOREIRAhttps://orcid.org/0000-0002-9979-1994Abstract This study investigated the antiglioblastoma potential of nine synthetic anthraquinone derivatives (SAQDs). SAQDs were tested for their in vitro cytotoxicity against PBMCs and GBM02 cells. For PBMC, SAQDs showed no cytotoxic effects up to 100 µM. Four most promising SAQDs (1, 4, 5, and 9) demonstrated significant activity against GBM02, with selectivity index >4.54 for 1, >1.30 for 4 and 5, and >1.19 for 9. These compounds induced morphological changes, incluing cell rounding, cytoplasmic vacuolation, and membrane rupture, and inhibited cell migration. Due to the pharmacological role of oxidative stress, electrochemical methods were used to compare the reductive and oxidative capacities of the SAQD with their antitumor activity. Considering the reported findings, it is feasible to confirm that some SAQDs have antitumor effects, supporting additional studies of AQ for developing novel anticancer medications. Due to the small number of compounds investigated, it was not possible to observe a relationship between electrochemical and biological data. However, the electrochemical data are new and could be used to prepare other compounds on this line. CV data revealed that the sulfone’s electron-withdrawing effect facilitated the reduction. At the same time, the sulfides had shown less positive potential for oxidation waves due to the presence of electron-donating groups.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652025000300601&lng=en&tlng=enanthraquinonescellsglioblastomaelectroactivity |
| spellingShingle | SUELLEN MARIA A. DA SILVA JOÃO KAYCKE S. DA SILVA JOICE FRAGOSO O. DE ARAÚJO ANDRESSA LETÍCIA L. DA SILVA ANDRESA KATHERINE A. DE ALMEIDA TAMIRES A. DO NASCIMENTO ANDRÉ FELIPPE A. XAVIER RENATA G. DE ALMEIDA GUILHERME AUGUSTI M. JARDIM EUFRÂNIO N. DA SILVA JÚNIOR VIVALDO MOURA-NETO ALYSSON WAGNER F. DUARTE PIERRE BARNABÉ ESCODRO JOÃO XAVIER DE ARAÚJO JÚNIOR MARÍLIA O.F. GOULART ALINE C. DE QUEIROZ MAGNA SUZANA ALEXANDRE-MOREIRA In vitro Antitumor Activity and Electrochemical Studies of Bio-Electroactive Anthraquinone Derivatives in Glioblastoma Anais da Academia Brasileira de Ciências anthraquinones cells glioblastoma electroactivity |
| title | In vitro Antitumor Activity and Electrochemical Studies of Bio-Electroactive Anthraquinone Derivatives in Glioblastoma |
| title_full | In vitro Antitumor Activity and Electrochemical Studies of Bio-Electroactive Anthraquinone Derivatives in Glioblastoma |
| title_fullStr | In vitro Antitumor Activity and Electrochemical Studies of Bio-Electroactive Anthraquinone Derivatives in Glioblastoma |
| title_full_unstemmed | In vitro Antitumor Activity and Electrochemical Studies of Bio-Electroactive Anthraquinone Derivatives in Glioblastoma |
| title_short | In vitro Antitumor Activity and Electrochemical Studies of Bio-Electroactive Anthraquinone Derivatives in Glioblastoma |
| title_sort | in vitro antitumor activity and electrochemical studies of bio electroactive anthraquinone derivatives in glioblastoma |
| topic | anthraquinones cells glioblastoma electroactivity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652025000300601&lng=en&tlng=en |
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