Potentiation of macrophage Piezo1 by atherogenic 7-ketocholesterol

Potentiation of macrophage Piezo1 by atherogenic 7-ketocholesterol

Summary: The mechanosensitive ion channel Piezo1 present in endothelial and smooth muscle cells, as well as in macrophages, is emerging as a novel, important player in the etiology of atherosclerosis. Here, we show that myeloid-specific deficiency of Piezo1 in atherogenic Ldlr−/− mice reduces plaque...

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Main Authors: Edyta Glogowska, Gregor P. Jose, Ana Rita Dias Araújo, Malika Arhatte, Raphael Divita, Coraline Borowczyk, Thibault Barouillet, Baile Wang, Frédéric Brau, Rémi Peyronnet, Amanda Patel, Bruno Mesmin, Takeshi Harayama, Bruno Antonny, Aimin Xu, Laurent Yvan-Charvet, Eric Honoré
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003134
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http://www.sciencedirect.com/science/article/pii/S2211124725003134

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