Antidiabetic Effect of Dihydrobetulonic Acid Derivatives as Pparα/γ Agonists

Antidiabetic Effect of Dihydrobetulonic Acid Derivatives as Pparα/γ Agonists

Dual PPARα/γ agonists can normalize both glucose and lipid metabolism in patients with type 2 diabetes mellitus. The development of such drugs faced the detection of various toxic effects in phase III clinical trials. However, two drugs of this class managed to pass all stages of clinical trials, wh...

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Main Authors: Mikhail V. Khvostov, Mikhail E. Blokhin, Sergey A. Borisov, Vladislav V. Fomenko, Yulia V. Meshkova, Natalia A. Zhukova, Sophia V. Nikonova, Sophia V. Pavlova, Maria A. Pogosova, Sergey P. Medvedev, Olga A. Luzina, Nariman F. Salakhutdinov
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Scientia Pharmaceutica
Subjects:
dual PPARα/γ agonists
type 2 diabetes mellitus
hypoglycemic activity
dihydrobetulonic acid
Online Access:https://www.mdpi.com/2218-0532/92/4/65
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