Simvastatin inhibits 20-Hydroxyeicosatetraenoic acid formation: docking and in vitro assay

Simvastatin inhibits 20-Hydroxyeicosatetraenoic acid formation: docking and in vitro assay

Abstract Introduction 20-Hydroxyeicosatetraenoic acid (20-HETE), a metabolite of arachidonic acid catalyzed mainly by cytochrome P450 (CYP) enzymes CYP4A11 and CYP4F2, plays a role in cardiovascular homeostasis. Elevated levels of 20-HETE are associated with hypertension. Accordingly, 20-HETE is a p...

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Main Authors: Yazun Jarrar, Mansour Almansour, Mansour Al-Sayed Ahmad, Belal O. Al-Najjar, Amin A. Al-Doaiss, Sireen Abdul Rahim Shilbayeh, Su-Jun Lee
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Pharmacology and Toxicology
Subjects:
20-HETE
CYP4
Docking
Liver microsome
Simvastatin
Online Access:https://doi.org/10.1186/s40360-025-00976-2
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https://doi.org/10.1186/s40360-025-00976-2

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