Borreliosis and doxycycline treatment disrupt gut microbiota and immune responses in nonhuman primates

Borreliosis and doxycycline treatment disrupt gut microbiota and immune responses in nonhuman primates

ABSTRACT Borrelia burgdorferi (Bb) is the spirochete that causes Lyme disease (LD). Transmission to humans occurs via bites of infected Ixodes spp. ticks. Doxycycline is often used to treat LD patients, which is sometimes delayed due to current diagnostic challenges. Recently, several lines of evide...

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Bibliographic Details
Main Authors: Ethan G. Napier, Isaac R. Cinco, Sheridan B. Wagner, Ethan V. Stuart, Qi Qiao, Joshua Taylor, Brian Stevenson, Ilhem Messaoudi
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
Borrelia burgdorferi
microbiome
doxycycline
single-cell RNA sequencing
macaque
Online Access:https://journals.asm.org/doi/10.1128/mbio.01437-25
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https://journals.asm.org/doi/10.1128/mbio.01437-25

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