Use of polygenic risk scores for differential diagnostics for patients with clinical diagnosis of familial hypercholesterolemia

Aim. To evaluate the polygenic contribution to low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels in patients with familial hypercholesterolemia (FH) based on polygenic risk scores (PRS), as well as to examine the potential of predicting referential FH diagnosis in non-car...

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Bibliographic Details
Main Authors:	M. Zaychenoka, A. N. Meshkov, A. V. Kiseleva, A. I. Ershova, E. A. Sotnikova, A. A. Zharikova, Yu. V. Vyatkin, V. I. Mikhailina, A. A. Bukaeva, M. S. Pokrovskaya, V. E. Ramenskiy, O. M. Drapkina
Format:	Article
Language:	Russian
Published:	«SILICEA-POLIGRAF» LLC 2025-02-01
Series:	Кардиоваскулярная терапия и профилактика
Subjects:	familial hypercholesterolemia polygenic risk scores population study low-density lipoprotein cholesterol total cholesterol
Online Access:	https://cardiovascular.elpub.ru/jour/article/view/4251
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Use of polygenic risk scores for differential diagnostics for patients with clinical diagnosis of familial hypercholesterolemia

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