Use of polygenic risk scores for differential diagnostics for patients with clinical diagnosis of familial hypercholesterolemia

Use of polygenic risk scores for differential diagnostics for patients with clinical diagnosis of familial hypercholesterolemia

Aim. To evaluate the polygenic contribution to low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels in patients with familial hypercholesterolemia (FH) based on polygenic risk scores (PRS), as well as to examine the potential of predicting referential FH diagnosis in non-car...

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Main Authors: M. Zaychenoka, A. N. Meshkov, A. V. Kiseleva, A. I. Ershova, E. A. Sotnikova, A. A. Zharikova, Yu. V. Vyatkin, V. I. Mikhailina, A. A. Bukaeva, M. S. Pokrovskaya, V. E. Ramenskiy, O. M. Drapkina
Format: Article
Language:Russian
Published: «SILICEA-POLIGRAF» LLC 2025-02-01
Series:Кардиоваскулярная терапия и профилактика
Subjects:
familial hypercholesterolemia
polygenic risk scores
population study
low-density lipoprotein cholesterol
total cholesterol
Online Access:https://cardiovascular.elpub.ru/jour/article/view/4251
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https://cardiovascular.elpub.ru/jour/article/view/4251

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