Impact of 2D versus 3D fibroblast models on Leishmania species invasion in vitro: Rab5 dynamics and actin activity in initial infection

Impact of 2D versus 3D fibroblast models on Leishmania species invasion in vitro: Rab5 dynamics and actin activity in initial infection

BackgroundThe protozoan Leishmania, in addition to infecting phagocytic cells such as macrophages, can also invade non-professional phagocytic cells like fibroblasts, a process previously described in 2D models. In a bidimensional environment, its interaction with the extracellular matrix and manipu...

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Bibliographic Details
Main Authors: Rebecca Thereza Silva Santa Brígida, Adeniele Lopes da Cruz Carneiro, Felipe Tuji de Castro Franco, Brenda Furtado Costa, Ana Paula Drummond Rodrigues
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Leishmania
fibroblasts
3D cell culture
Rab5
actin cytoskeleton
parasite invasion
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1654654/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1654654/full

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