Computational analysis of zoanthamine alkaloids from Zoanthus sp. as potential DKK1 and GSK-3β inhibitors for osteoporosis therapy via Wnt signaling

Computational analysis of zoanthamine alkaloids from Zoanthus sp. as potential DKK1 and GSK-3β inhibitors for osteoporosis therapy via Wnt signaling

Abstract Marine invertebrates are a rich source of structurally diverse secondary metabolites with broad biological activities, making them valuable for drug discovery. The genus Zoanthus is particularly noteworthy, producing numerous bioactive alkaloids, including the zoanthamines, which show promi...

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Bibliographic Details
Main Authors: Ngoc-Thac Pham, Huong-Giang Le, Bo-Rong Peng, Lo-Yun Chen, Mohamed El-Shazly, Jui-Hsin Su, Mei-Hsien Lee, Kuei-Hung Lai
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Osteoporosis
DKK1
GSK-3β
Docking
Molecular dynamics
DFT
Online Access:https://doi.org/10.1038/s41598-025-97537-8
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https://doi.org/10.1038/s41598-025-97537-8

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