The role of collagen type VI alpha 6 chain as a potential tumor suppressor in breast cancer: an immune regulation perspective

The role of collagen type VI alpha 6 chain as a potential tumor suppressor in breast cancer: an immune regulation perspective

Abstract Background Collagen type VI alpha 6 chain (COL6A6), an essential component of epithelial cell basal lamina, is hypothesized to function as a tumor suppressor in various cancers, yet its role in breast cancer remains unclear. This study aimed to elucidate COL6A6 expression patterns, assess i...

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Main Authors: Jian-Di Li, Li-Li Deng, Jia-Yuan Luo, Chao-Hua Mo, Bang-Teng Chi, Wan-Ying Huang, Rong-Quan He, Di-Yuan Qin, Chang Song, Wen Zou, Gang Chen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Breast cancer
COL6A6
Immunohistochemical staining
scRNA-seq
Tumor microenvironment
GSEA
Online Access:https://doi.org/10.1186/s12885-025-14680-1
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https://doi.org/10.1186/s12885-025-14680-1

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