Rescuing ACE2‐Deficiency‐Mediated Nucleus Pulposus Senescence and Intervertebral Disc Degeneration by a Nanotopology‐Enhanced RNAi System

Rescuing ACE2‐Deficiency‐Mediated Nucleus Pulposus Senescence and Intervertebral Disc Degeneration by a Nanotopology‐Enhanced RNAi System

Abstract Nucleus pulposus cell (NPC) senescence contributes to intervertebral disc degeneration (IVDD). However, the underlying molecular mechanisms are not fully understood. In this study, it is demonstrated that angiotensin‐converting enzyme 2 (ACE2) counteracted the aging of NPCs and IVDD at the...

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Bibliographic Details
Main Authors: Kaiqiang Sun, Zijian Kang, Chen Yan, Yan Yu, Linhui Han, Yangyang Shi, Liang Chen, Jiangang Shi, Yu Chen, Jingchuan Sun
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
Intervertebral disc degeneration
Cellular senescnece
Nanotopology‐enhanced RNAi system
ACE2
Gene therapy
Online Access:https://doi.org/10.1002/advs.202412908
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https://doi.org/10.1002/advs.202412908

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