Thrombin generation to evaluate the complex hemostatic balance of hemophilia A plasma containing direct oral anticoagulant and supplemented by factor VIII

Thrombin generation to evaluate the complex hemostatic balance of hemophilia A plasma containing direct oral anticoagulant and supplemented by factor VIII

Background: The incidence of cardiovascular diseases is increasing in persons with hemophilia A (HA). Therefore, anticoagulant therapy based on direct oral anticoagulants (DOACs) may be needed, despite the bleeding risk. In case of surgery or bleeding, such patients may be concomitantly treated with...

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Bibliographic Details
Main Authors: Sylvain Lamoine, Vincent Jury, Virginie Fourneyron, Jonathan Douxfils, Dorian Teissandier, Laurie Talon, Thomas Sinegre, Aurélien Lebreton
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
direct oral anticoagulant
emicizumab
hemophilia A
monitoring
thrombin
Online Access:http://www.sciencedirect.com/science/article/pii/S2475037924002711
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