CREPT is required for the metastasis of triple-negative breast cancer through a co-operational-chromatin loop-based gene regulation

CREPT is required for the metastasis of triple-negative breast cancer through a co-operational-chromatin loop-based gene regulation

Abstract Triple-negative breast cancer (TNBC) is recognized for its aggressiveness, yet the mechanism underlying metastasis remains unclear. Here, we report that CREPT/RPRD1B, which exhibits somatic gene copy-number amplifications and elevated expression, correlates with poor patient survival and dr...

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Main Authors: Jianghua Li, Lu Xu, Jiayu Wang, Xuning Wang, Yuting Lin, Alex Yutian Zou, Fangli Ren, Yinyin Wang, Jun Li, Zhijie Chang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Cancer
Online Access:https://doi.org/10.1186/s12943-025-02361-3
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https://doi.org/10.1186/s12943-025-02361-3

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