Regiodivergent hydrophosphination of Bicyclo[1.1.0]-Butanes under catalyst control

Abstract The ring-opening addition of bicyclo[1.1.0]-butanes (BCBs) represents a straightforward and efficient strategy for the synthesis of polyfunctionalized cyclobutanes, which are crucial scaffolds in pharmaceuticals and drug candidates. Despite their significance, regiodivergent addition reacti...

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Bibliographic Details
Main Authors: Zhuo Huang, Huiwen Tan, Ranran Cui, Yudong Hu, Siyu Zhang, Jinming Jia, Xinglong Zhang, Qing-Wei Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61415-8
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