Comprehensive analysis of single-cell and bulk RNA sequencing data reveals an EGFR signature for predicting immunotherapy response and prognosis in pan-cancer

Comprehensive analysis of single-cell and bulk RNA sequencing data reveals an EGFR signature for predicting immunotherapy response and prognosis in pan-cancer

IntroductionImmune checkpoint inhibitors (ICIs) have changed the paradigm of cancer treatment, but their effectiveness in some patients with epidermal growth factor receptor (EGFR) mutations is unsatisfactory. Therefore, it is necessary to develop a new biomarker for combined immunotherapy strategie...

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Bibliographic Details
Main Authors: Changchun Ye, Xiaoya Chen, Zilu Chen, Shiyuan Liu, Ranran Kong, Wenhao Lin, Minxia Zhu, Xuejun Sun, Zhengshui Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint inhibitors (ICIs)
epidermal growth factor receptor (EGFR)
pan-cancer
scRNA-seq
immunotherapy response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604394/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604394/full

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