Impact of HIV-1 capsid polymorphisms on viral infectivity and susceptibility to lenacapavir

Impact of HIV-1 capsid polymorphisms on viral infectivity and susceptibility to lenacapavir

ABSTRACT Lenacapavir (LEN) is a first-in-class capsid (CA) inhibitor for the treatment and prevention of HIV-1 infection. While LEN has shown potent antiviral activity across all major HIV-1 subtypes, the impact of existing HIV-1 CA sequence diversity on the activity of LEN remains to be determined....

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Main Authors: Derek Hansen, Matthew R. Hendricks, Silvia Chang, Arthur Cai, Jason K. Perry, Thomas Aeschbacher, Ross Martin, Tomas Cihlar, Stephen R. Yant
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
polymorphism
antiretroviral resistance
lenacapavir
HIV
viral fitness
Online Access:https://journals.asm.org/doi/10.1128/mbio.00187-25
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https://journals.asm.org/doi/10.1128/mbio.00187-25

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