Classification of pediatric soft and bone sarcomas using DNA methylation-based profiling

Classification of pediatric soft and bone sarcomas using DNA methylation-based profiling

Abstract Pediatric sarcomas present heterogeneous morphology, genetics and clinical behavior posing a challenge for an accurate diagnosis. DNA methylation is an epigenetic modification that coordinates chromatin structure and regulates gene expression, determining cell type and function. DNA methyla...

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Main Authors: Felipe Luz Torres Silva, Mayara Ferreira Euzébio, Juliana Silveira Ruas, Mayra Troiani Franco, Alejandro Enzo Cassone, Thais Junqueira, Danielle Ribeiro Lucon, Izilda Aparecida Cardinalli, Luis Henrique Pereira, Priscila Pini Zenatti, Patricia Yoshioka Jotta, Mariana Maschietto
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Cancer
Subjects:
Pediatric sarcomas
Soft and bone sarcomas
Molecular classification
DNA methylation
Copy number alteration
Online Access:https://doi.org/10.1186/s12885-024-13159-9
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https://doi.org/10.1186/s12885-024-13159-9

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