An accurate DNA and RNA based targeted sequencing assay for clinical detection of gene fusions in solid tumors

An accurate DNA and RNA based targeted sequencing assay for clinical detection of gene fusions in solid tumors

Abstract Gene fusions are one of the most important molecular biomarkers for tumor diagnosis, classification and targeted therapy. How to accurately detect them is a key issue in clinical work. In this study, a custom-designed integration of DNA and RNA-based next generation sequencing (NGS) assay i...

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Bibliographic Details
Main Authors: Gang Ji, Qianlan Yao, Min Ren, Qianming Bai, Xiaoli Zhu, Xiaoyan Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Gene fusion
DNA and RNA based
Next generation sequencing
Targeted therapy
Hospital developed test
Online Access:https://doi.org/10.1038/s41598-025-91640-6
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https://doi.org/10.1038/s41598-025-91640-6

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