Beta‐Lactam Antibiotics Promote Extracellular Vesicle Production of Staphylococcus aureus Through ROS‐Mediated Lipid Metabolic Reprogramming

Beta‐Lactam Antibiotics Promote Extracellular Vesicle Production of Staphylococcus aureus Through ROS‐Mediated Lipid Metabolic Reprogramming

ABSTRACT Bacterial extracellular vesicles (EVs) are natural reservoirs of biological active substances. They exhibit promising application in developing bioproducts such as vaccine, drug‐delivery system and anticancer agent. However, the low yield of naturally secreted EVs during bacterial growth is...

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Main Authors: Xiaonan Huang, Zhen Hu, Weilong Shang, Juan Chen, Qiwen Hu, Yumin Zhou, Ruolan Ding, Jing Yin, Mengyang Li, He Liu, Jianxiong Dou, Huagang Peng, Yifan Rao, Lu Liu, Yuting Wang, Li Tan, Yuhua Yang, Jianghong Wu, Chuan Xiao, Yi Yang, Xiancai Rao
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Journal of Extracellular Vesicles
Subjects:
β‐lactam antibiotics
extracellular vesicle
lipid metabolism
penicillin binding proteins
reactive oxygen species
Staphylococcus aureus
Online Access:https://doi.org/10.1002/jev2.70077
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https://doi.org/10.1002/jev2.70077

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