The effect of guanfacine treatment on ocular parameters in pediatric and adolescents patients with attention-deficit/hyperactivity disorder
Abstract Background This study aimed to evaluate the effects of guanfacine on the anterior and posterior segments of the eye. Methods This prospective study included 32 children and adolescents with Attention-deficit/hyperactivity disorder (ADHD). The participants underwent a detailed ophthalmologic...
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2025-01-01
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| author | Işıl Merve Torun Zeynep Vatansever Pinar Şeyma İlhan |
| author_facet | Işıl Merve Torun Zeynep Vatansever Pinar Şeyma İlhan |
| author_sort | Işıl Merve Torun |
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| description | Abstract Background This study aimed to evaluate the effects of guanfacine on the anterior and posterior segments of the eye. Methods This prospective study included 32 children and adolescents with Attention-deficit/hyperactivity disorder (ADHD). The participants underwent a detailed ophthalmologic evaluation before and 6 months after the beginning of guanfacine treatment. The following data were recorded for each participant: refraction error, intraocular pressure (IOP), anterior chamber depth (ACD), central corneal thickness (CCT), corneal aberrations using corneal topography, retinal nerve fiber layer (RNFL) analysis of seven quadrants (central, nasal, naso-superior, naso-inferior, temporal, temporo-superior, temporo-inferior), central macular thickness (CMT), and choroidal thickness (CT). Assessments were made of these parameters obtained from images using an optical coherence tomography (OCT) instrument. Results A significant increase in total root mean square (RMS) (p = 0.029*), RMS low-order aberration (LOA) (p = 0.014*), Coma 0° (p < 0.001*), and Coma 90° (p = 0.037*) corneal aberrations was observed at the sixth month of guanfacine treatment in comparison with the baseline examination. Other ocular parameters demonstrated no significant change from the baseline examination findings at the sixth month of guanfacine treatment. (p > 0.05, for each). Conclusion Oral guanfacine in the treatment of ADHD had no effect on ocular structures such as the retina, choroid, optic nerve, refraction, or corneal thickness, although it increased corneal aberrations. The results require support through further studies with extended follow-up and a larger patient group. |
| format | Article |
| id | doaj-art-ccb9d19c3a164db2bd46f3932ef83fb5 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Ophthalmology |
| spelling | doaj-art-ccb9d19c3a164db2bd46f3932ef83fb52025-02-02T12:13:30ZengBMCBMC Ophthalmology1471-24152025-01-012511810.1186/s12886-025-03886-3The effect of guanfacine treatment on ocular parameters in pediatric and adolescents patients with attention-deficit/hyperactivity disorderIşıl Merve Torun0Zeynep Vatansever Pinar1Şeyma İlhan2Department of Ophthalmology, Medical Health Sciences University, Sultan Abdulhamid Han Training and Research HospitalDepartment of Child and Adolescent Psychiatry, Maltepe University, Faculty of MedicineDepartment of Child and Adolescent Psychiatry, Medical Health Sciences University, Kartal Dr Lütfi Kırdar City HospitalAbstract Background This study aimed to evaluate the effects of guanfacine on the anterior and posterior segments of the eye. Methods This prospective study included 32 children and adolescents with Attention-deficit/hyperactivity disorder (ADHD). The participants underwent a detailed ophthalmologic evaluation before and 6 months after the beginning of guanfacine treatment. The following data were recorded for each participant: refraction error, intraocular pressure (IOP), anterior chamber depth (ACD), central corneal thickness (CCT), corneal aberrations using corneal topography, retinal nerve fiber layer (RNFL) analysis of seven quadrants (central, nasal, naso-superior, naso-inferior, temporal, temporo-superior, temporo-inferior), central macular thickness (CMT), and choroidal thickness (CT). Assessments were made of these parameters obtained from images using an optical coherence tomography (OCT) instrument. Results A significant increase in total root mean square (RMS) (p = 0.029*), RMS low-order aberration (LOA) (p = 0.014*), Coma 0° (p < 0.001*), and Coma 90° (p = 0.037*) corneal aberrations was observed at the sixth month of guanfacine treatment in comparison with the baseline examination. Other ocular parameters demonstrated no significant change from the baseline examination findings at the sixth month of guanfacine treatment. (p > 0.05, for each). Conclusion Oral guanfacine in the treatment of ADHD had no effect on ocular structures such as the retina, choroid, optic nerve, refraction, or corneal thickness, although it increased corneal aberrations. The results require support through further studies with extended follow-up and a larger patient group.https://doi.org/10.1186/s12886-025-03886-3Attention-deficit/hyperactivity disorderChoroidCorneal aberrationGuanfacineRetina |
| spellingShingle | Işıl Merve Torun Zeynep Vatansever Pinar Şeyma İlhan The effect of guanfacine treatment on ocular parameters in pediatric and adolescents patients with attention-deficit/hyperactivity disorder BMC Ophthalmology Attention-deficit/hyperactivity disorder Choroid Corneal aberration Guanfacine Retina |
| title | The effect of guanfacine treatment on ocular parameters in pediatric and adolescents patients with attention-deficit/hyperactivity disorder |
| title_full | The effect of guanfacine treatment on ocular parameters in pediatric and adolescents patients with attention-deficit/hyperactivity disorder |
| title_fullStr | The effect of guanfacine treatment on ocular parameters in pediatric and adolescents patients with attention-deficit/hyperactivity disorder |
| title_full_unstemmed | The effect of guanfacine treatment on ocular parameters in pediatric and adolescents patients with attention-deficit/hyperactivity disorder |
| title_short | The effect of guanfacine treatment on ocular parameters in pediatric and adolescents patients with attention-deficit/hyperactivity disorder |
| title_sort | effect of guanfacine treatment on ocular parameters in pediatric and adolescents patients with attention deficit hyperactivity disorder |
| topic | Attention-deficit/hyperactivity disorder Choroid Corneal aberration Guanfacine Retina |
| url | https://doi.org/10.1186/s12886-025-03886-3 |
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