Respiration defects limit serine synthesis required for lung cancer growth and survival

Respiration defects limit serine synthesis required for lung cancer growth and survival

Abstract Mitochondrial function supports energy and anabolic metabolism. Pathogenic mitochondrial DNA (mtDNA) mutations impair these processes, causing mitochondrial diseases. Their role in human cancers is less clear; while some cancers harbor high mtDNA mutation burden, others do not. Here we show...

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Main Authors: Eduardo Cararo Lopes, Fuqian Shi, Akshada Sawant, Maria Ibrahim, Maria Gomez-Jenkins, Zhixian Hu, Pranav Manchiraju, Vrushank Bhatt, Wenping Wang, Christian S. Hinrichs, Douglas C. Wallace, Xiaoyang Su, Joshua D. Rabinowitz, Chang S. Chan, Jessie Yanxiang Guo, Shridar Ganesan, Edmund C. Lattime, Eileen White
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62911-7
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