Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata

Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata

IntroductionAlopecia areata (AA) is an autoimmune disorder characterized by non-scarring hair loss ranging from mild, self-limiting episodes to severe and chronic forms. While prior research has primarily focused on lesional skin, the contribution of systemic immune cells remains underexplored.Metho...

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Main Authors: Jesus Gay-Mimbrera, Pedro Jesús Gómez-Arias, Pablo Álvarez-Heredia, Alexander Batista-Duharte, Irene Rivera-Ruiz, Macarena Aguilar-Luque, Miguel Juan-Cencerrado, Carmen Mochón-Jiménez, Álvaro Cebrián-García, Eloísa Andújar-Pulido, Mónica Pérez-Alegre, Alejandra Pera, Juan Ruano
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Alopecia areata
severity
peripheral blood
immune cells
single-cell RNA sequencing
chromatin accessibility
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565241/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565241/full

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