Rotation-invariance is essential for accurate detection of spatially variable genes in spatial transcriptomics
In spatial transcriptomics, tissue samples are randomly positioned. Rotation-sensitive methods can lead to unreliable spatially variable gene (SVG) detection. We highlight their inherent technical pitfalls and discuss strategies for rotation-invariant methods, enhancing the robustness of SVG detecti...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-62574-4 |
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