Identification of candidate nsSNPs of the human FNDC5 gene and their structural and functional consequences using in silico analysis

Identification of candidate nsSNPs of the human FNDC5 gene and their structural and functional consequences using in silico analysis

Abstract Fibronectin type-III domain containing protein-5 (FNDC5), predominantly expressed in skeletal muscles, encodes FNDC5 transmembrane-protein. A segment of this protein is cleaved and secreted into blood as irisin, which promotes browning of white adipose tissue, leading to energy expenditure....

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Bibliographic Details
Main Authors: Sadaf Majeed, Hira Moin, Maaz Waseem, Zoya Khalid, Sumra Wajid Abbasi, Kashaf Rasool
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
FNDC5
In silico
Irisin
Obesity
SNPs
Online Access:https://doi.org/10.1038/s41598-024-83254-1
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