Genotype–phenotype analysis and functional study of three novel LRP6 variants in non-syndromic oligodontia

Genotype–phenotype analysis and functional study of three novel LRP6 variants in non-syndromic oligodontia

Introduction:Tooth agenesis (TA) is a common craniofacial malformation in humans, characterized by the absence of one or more permanent teeth. Recent studies have identified the low-density lipoprotein receptor-related protein 6 (LRP6) gene as an autosomal dominant contributor to TA. Herein we aimed...

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Main Authors: Yunyun Yuan, Ya Zhao, Lingqiang Meng, Shuyun Zheng, Hui Li, Jiabao Ren, Beibei Li, Chenyun Dou, Yan Hou, Wenjing Chen, Jing Zhang, Yulin Ding, Wenjing Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Genetics
Subjects:
tooth agenesis
non-syndromic oligodontia
LRP6
β-catenin
genotype-phenotype
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1598907/full
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https://www.frontiersin.org/articles/10.3389/fgene.2025.1598907/full

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