Reevaluating antiviral thresholds in HBV DNA-negative inactive HBsAg carriers: a multicenter histopathological analysis

Reevaluating antiviral thresholds in HBV DNA-negative inactive HBsAg carriers: a multicenter histopathological analysis

Abstract Background The definition of inactive HBsAg carriers (IHC) varies globally, particularly regarding HBV DNA thresholds. Whether HBV DNA negativity reliably predicts histological quiescence remains uncertain. Aims This study evaluated liver pathology in IHC patients to reassess antiviral ther...

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Main Authors: Shan Ren, Sujun Zheng, Xinyang Zhang, Junliang Fu, Rongshan Fan, Qingfa Ruan, Wenqi Huang, Haibing Gao, Xiulan Xue, Fang Yang, Yao Xie, Minghui Li, Xinyue Chen
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Virology Journal
Subjects:
Chronic hepatitis B
Inactive HBsAg carriers
Liver histopathology
Antiviral thresholds
Fibrosis
Non-invasive biomarkers
Online Access:https://doi.org/10.1186/s12985-025-02853-0
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https://doi.org/10.1186/s12985-025-02853-0

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