Single-dose radiotherapy is more effective than fractionation when combined with anti-PD-1 immunotherapy in glioblastoma

Single-dose radiotherapy is more effective than fractionation when combined with anti-PD-1 immunotherapy in glioblastoma

Abstract Glioblastoma (GBM), the most common adult primary brain tumor, has an average survival of only 15–18 months. Recently, the combination of immune checkpoint blockers paired with radiotherapy has shown promise in preclinical murine GBM models. Human clinical trials have largely failed. One re...

Full description

Saved in:
Bibliographic Details
Main Authors: Carolina Cocito, Mylene Branchtein, Xi Kathy Zhou, Tatyana Gongora, Nadia Dahmane, Jeffrey Peter Greenfield
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
GL261: checkpoint blockage
IfIh1
Tumor microenvironment
Online Access:https://doi.org/10.1038/s41598-025-06909-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-06909-7

Similar Items