Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis

Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis

Synovium is home to immune and stromal cell types that orchestrate inflammation following a joint injury; in particular, macrophages are central protagonists in this process. We sought to define the cellular and temporal dynamics of the synovial immune niche in a mouse model of post-traumatic osteoa...

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Bibliographic Details
Main Authors: Alexander J Knights, Easton C Farrell, Olivia M Ellis, Michelle J Song, C Thomas Appleton, Tristan Maerz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
osteoarthritis
synovium
macrophages
single-cell RNA-seq
joint injury
Online Access:https://elifesciences.org/articles/93283
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https://elifesciences.org/articles/93283

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