POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis
Evasion of programmed cell death (PCD) is a hallmark of cancer, yet the mechanisms underlying resistance to ferroptosis – an iron-dependent form of PCD triggered by excessive lipid peroxidation – remain incompletely understood. Here, we identify a previously unrecognized nucleolar-mitochondrial sign...
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| Main Authors: | Tuo Zhang, Yanyun Gao, Marcell Harhai, Alexis A. Jourdain, Thomas M. Marti, Erik Vassella, Zhang Yang, Qinghua Zhou, Patrick Dorn, Ren-Wang Peng |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221323172500271X |
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