POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis

POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis

Evasion of programmed cell death (PCD) is a hallmark of cancer, yet the mechanisms underlying resistance to ferroptosis – an iron-dependent form of PCD triggered by excessive lipid peroxidation – remain incompletely understood. Here, we identify a previously unrecognized nucleolar-mitochondrial sign...

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Bibliographic Details
Main Authors: Tuo Zhang, Yanyun Gao, Marcell Harhai, Alexis A. Jourdain, Thomas M. Marti, Erik Vassella, Zhang Yang, Qinghua Zhou, Patrick Dorn, Ren-Wang Peng
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Ferroptosis
Iron metabolism
mitophagy
POLR1A
ATF4
TFAM
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172500271X
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