Mutation of the SUMOylation site of Aurora-B disrupts spindle formation and chromosome alignment in oocytes

Mutation of the SUMOylation site of Aurora-B disrupts spindle formation and chromosome alignment in oocytes

Abstract Aurora-B is a kinase that regulates spindle assembly and kinetochore-microtubule (KT-MT) attachment during mitosis and meiosis. SUMOylation is involved in the oocyte meiosis regulation through promoting spindle assembly and chromosome segregation, but its substrates to support this function...

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Main Authors: Shan-Shan Chen, Li Li, Bo Yao, Jia-Lun Guo, Ping-Shuang Lu, Hao-Lin Zhang, Kun-Huan Zhang, Yuan-Jing Zou, Nan-Jian Luo, Shao-Chen Sun, Lin-Lin Hu, Yan-Ping Ren
Format: Article
Language:English
Published: Nature Publishing Group 2024-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02217-7
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https://doi.org/10.1038/s41420-024-02217-7

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