Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

Abstract Acute Myeloid Leukemia (AML) remains a formidable clinical challenge, predominantly due to the emergence of resistance to existing therapeutic regimens, including BCL‐2 inhibitors like Venetoclax. Here, a novel approach is introduced by engineering BH3 mimetics utilizing non‐canonical amino...

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Main Authors: Zhe Wang, Ruizhi Lai, Xinpei Wang, Xu Chen, Youjian Zhou, Shengbin Li, Xiaohui Qiu, Zekai Zeng, Jianye Yuan, Jinghuan Mao, Zhidong Chen, Junqing Wang
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
acute myeloid leukemia
drug resistance
MCL‐1 & BCL‐xL inhibition
non‐canonical amino acids
targeted penetrating peptides
Online Access:https://doi.org/10.1002/advs.202503682
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https://doi.org/10.1002/advs.202503682

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