Rare APOE p.Gly4Glu: A putative disease-causing variant for early-onset Alzheimer’s disease identified by next-generation sequencing

Rare APOE p.Gly4Glu: A putative disease-causing variant for early-onset Alzheimer’s disease identified by next-generation sequencing

Objectives: We aimed to identify the early-onset Alzheimer’s disease (EOAD)-causing variants in the Eastern Taiwanese population. Materials and Methods: Twenty-one patients diagnosed with EOAD in the memory clinic at Hualien Tzu Chi Hospital were enrolled during 2014–2018. We conducted whole-exome s...

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Bibliographic Details
Main Authors: Chu-Ting Wu, Liang-Hsuan Hu, Hui-Ying Weng, Yen-Ming Liu, Yung-Feng Lin, Shih-Feng Tsai, Raymond Y. Lo, Yung-Hao Ching
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-04-01
Series:Tzu Chi Medical Journal
Subjects:
allele frequency
apolipoproteins e
early-onset alzheimer disease
exome sequencing
high-throughput nucleotide sequencing
Online Access:https://journals.lww.com/10.4103/tcmj.tcmj_117_24
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https://journals.lww.com/10.4103/tcmj.tcmj_117_24

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