Revisiting pulmonary fibrosis: inflammatory dynamics of the lipofibroblast-to-inflammatory lipofibroblast-to-activated myofibroblast reversible switch

Revisiting pulmonary fibrosis: inflammatory dynamics of the lipofibroblast-to-inflammatory lipofibroblast-to-activated myofibroblast reversible switch

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by excessive extracellular matrix (ECM) deposition and irreversible lung damage. A key driver of disease progression is the phenotypic shift of lipofibroblasts (LIFs) into activated myofibroblasts (...

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Bibliographic Details
Main Authors: Georgios-Dimitrios Panagiotidis, Esmeralda Vasquez-Pacheco, Xuran Chu, Werner Seeger, Elie El Agha, Saverio Bellusci, Arun Lingampally
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
idiopathic pulmonary fibrosis
lipofibroblast
inflammatory lipofibroblast
activated myofibroblast
TGF-β
IL-17A
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609509/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609509/full

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