Molecular features defining the efficiency of bioPROTACs

Molecular features defining the efficiency of bioPROTACs

Abstract BioPROTACs consist of a target-binding unit and a component of the ubiquitin-proteasome system. However, the specific biophysical features influencing their effectiveness are poorly understood. We investigated the design principles defining the target-binding moiety of bioPROTACs. We used o...

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Main Authors: Dorothea Winkelvoß, David Vukovic, Anna-Carina Hänny, Luca Riermeier, Anto Udovcic, Jonas Kolibius, Annemarie Honegger, Peer R. E. Mittl, Erich Michel, Simon Hansen, Andreas Plückthun
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08352-w
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https://doi.org/10.1038/s42003-025-08352-w

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