A genetically encoded fluorescent sensor enables sensitive and specific detection of IDH mutant associated oncometabolite D-2-hydroxyglutarate

A genetically encoded fluorescent sensor enables sensitive and specific detection of IDH mutant associated oncometabolite D-2-hydroxyglutarate

Abstract D-2-hydroxyglutarate (D-2-HG) is an oncometabolite that accumulates due to mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2). D-2-HG may be used as a surrogate marker for IDH1/2 mutant cancers, yet simple and specific methods for D-2-HG detection are limited. Here, we present the devel...

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Main Authors: Kristian A. Choate, Wren W. L. Konickson, Zoe L. Moreno, Olivia S. Brill, Brett C. Cromell, Bella M. Detienne, Matthew J. Jennings, Paul B. Mann, Robert J. Winn, David O. Kamson, Evan P.S. Pratt
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Cancer
Subjects:
Isocitrate dehydrogenase
D-2-hydroxyglutarate
Glioma
Fluorescent biosensor
Diagnostic
Online Access:https://doi.org/10.1186/s12885-025-13877-8
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https://doi.org/10.1186/s12885-025-13877-8

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