Vps34-orchestrated lipid signaling processes regulate the transitional heterogeneity and functional adaptation of effector regulatory T cells.

Vps34-orchestrated lipid signaling processes regulate the transitional heterogeneity and functional adaptation of effector regulatory T cells.

Regulatory T cell (Treg) heterogeneity exists in lymphoid and non-lymphoid tissues, but we have limited understanding of context-dependent functions and spatiotemporal regulators of heterogenous Treg states, especially during perinatal life when immune tolerance is established. Here, we revealed tha...

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Main Authors: Erienne G Norton, Nicole M Chapman, Hao Shi, Xiaoxi Meng, Hongling Huang, Anil Kc, Sherri Rankin, Jordy Saravia, Sujing Yuan, Haoran Hu, Peter Vogel, Hongbo Chi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003074
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https://doi.org/10.1371/journal.pbio.3003074

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