Antimicrobial susceptibility and resistance mechanisms to antipseudomonal β-lactams in Pseudomonas aeruginosa isolates from blood

Antimicrobial susceptibility and resistance mechanisms to antipseudomonal β-lactams in Pseudomonas aeruginosa isolates from blood

ABSTRACT Bloodstream infection caused by Pseudomonas aeruginosa with antimicrobial resistance can be difficult to treat. Herein, we investigated antimicrobial susceptibility to major antipseudomonal β-lactams and analyzed the relationship between resistance mechanisms and susceptibilities in P. aeru...

Full description

Saved in:

Bibliographic Details
Main Authors:	Mika Murata, Kosuke Kosai, Fujiko Mitsumoto-Kaseida, Norihito Kaku, Hiroo Hasegawa, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-05-01
Series:	Microbiology Spectrum
Subjects:	bloodstream infection resistance to antipseudomonal β-lactams gene expression ceftolozane/tazobactam cefiderocol
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.02790-24
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Detection of antibiotic resistance genes in MRSA whole-genome sequencing: database comparison and antimicrobial susceptibility correlation
by: Norihito Kaku, et al.
Published: (2024-12-01)

In vitro activity of ceftolozane/tazobactam against ESBL-producing enterobacterales in China: SMART 2016–2019
by: Wei Yu, et al.
Published: (2025-05-01)

Mechanisms of ceftolozane/tazobactam resistance in Pseudomonas aeruginosa isolates from South Korea
by: Yu Mi Wi, et al.
Published: (2024-12-01)

Evaluation of automated streaking patterns in urine culture for clinical workflow optimization
by: Yasuhide Kawamoto, et al.
Published: (2025-08-01)

Activity of ceftolozane/tazobactam against commonly encountered antimicrobial resistant Gram-negative bacteria in Lebanon
by: George F Araj, et al.
Published: (2020-06-01)

Ceftazidime-Induced Overexpression of MexJK-OprM Confers Resistance to Ceftolozane/Tazobactam in an Isolate of Pseudomonas aeruginosa
by: Sato T, et al.
Published: (2025-08-01)

Ceftolozane/tazobactam use and emergence of resistance: a 4-year analysis of antimicrobial susceptibility in Pseudomonas aeruginosa isolates in a tertiary hospital
by: Alessandra Imeneo, et al.
Published: (2025-04-01)

Clinical Evaluation of a Rapid Reciprocal-Flow PCR Assay and Real-Time PCR Assay with Quenching Probe for Detection of <i>Mycobacterium tuberculosis</i> Complex
by: Kosuke Kosai, et al.
Published: (2025-01-01)

Assessment of in vitro antimicrobial activities of ceftolozane/tazobactam and ceftazidime/avibactam against carbapenem-resistant Pseudomonas aeruginosa clinical isolates
by: Dalia Salem, et al.
Published: (2025-04-01)

Antimicrobial susceptibility of enterobacterales causing bloodstream infection in United States medical centres: comparison of aztreonam-avibactam with beta-lactams active against carbapenem-resistant enterobacterales
by: Helio S. Sader, et al.
Published: (2024-11-01)

Risk Factors and Outcomes of Multidrug-resistant Pseudomonas aeruginosa in Kelantan, Malaysia: A Multicenter Case–control Study
by: Siti Norfairuz Md. Salim, et al.
Published: (2025-01-01)

Antimicrobial susceptibility of gram-negative bacteria: Analysis from patients in a laboratory network in Brazil
by: Amanda Azevedo Bittencourt, et al.
Published: (2025-03-01)

Multidrug-resistant Pseudomonas aeruginosa in immunocompromised cancer patients: epidemiology, antimicrobial resistance, and virulence factors
by: Asmaa Abdulhak, et al.
Published: (2025-06-01)

Cefiderocol susceptibility of Stenotrophomonas maltophilia species complex and carbapenem-resistant Pseudomonas aeruginosa isolates from blood cultures at a university hospital in Tokyo, Japan
by: Wataru Aoki, et al.
Published: (2025-09-01)

Piperacillin-tazobactam: prospects for use in real-world practice
by: Yu. M. Gomon
Published: (2023-10-01)

Effectiveness of traditional non-carbapenem β-lactams vs. novel β-lactams for the treatment of carbapenem-resistant Pseudomonas aeruginosa: a retrospective cohort study
by: Namareq F. Aldardeer, et al.
Published: (2024-12-01)

Comparison of antimicrobial resistance in Pseudomonas aeruginosa from intensive care and non-intensive care units and its impact on treatment decisions
by: Racha Eid, et al.
Published: (2025-04-01)

Unveiling results and insights from multinational, multicenter Study of Prescribing patterns and Effectiveness of Ceftolozane/Tazobactam Real-world Analysis (SPECTRA)
by: Alex Soriano, et al.
Published: (2025-03-01)

From In Vitro Cytotoxicity to In Vivo Zebrafish Assays: A Study on 3,3-Dichloro β-, γ- and δ-Lactams and Their Biological Activity Profiles
by: Faïza Diaba, et al.
Published: (2025-03-01)

In vitro and in vivo investigation of the antibacterial, antivirulence, and antiquorum sensing activities of β-carotene against difficult-to-treat resistant Pseudomonas aeruginosa
by: Khaled B. Al-Monofy, et al.
Published: (2025-08-01)

Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics
by: Julia Werner, et al.
Published: (2024-12-01)

Characterization of YdgH: a mediator of beta-lactam susceptibility in Enterobacterales
by: Jacob E. Lazarus, et al.
Published: (2025-01-01)

Dynamics of Acquires Resistance in the Main Gramnegative Pathogens of Surgical Infections to Beta-Lactams in 2004-2008
by: N. S. Bogomolova, et al.
Published: (2020-05-01)

Investigation of Beta-Lactam and Tetracycline Group Antibiotic Residues in Bovine Liver, Kidney and Muscle Tissue
by: Sema Ağaoğlu, et al.
Published: (2021-12-01)

Whole-genome sequence analysis of morphological changes in Haemophilus influenzae after beta-lactam exposure
by: Lucia Malisova, et al.
Published: (2024-12-01)

Antibacterial properties of substituted phenethylamine-based β-lactam derivatives in oral infections
by: Merve Yildirim, et al.
Published: (2025-01-01)

Retrospective Examınatıon of Children with Beta Lactam-Drug Allergy: A Single-Center Experience
by: Şeyma Dilek, et al.
Published: (2024-09-01)

Investigation of Beta-lactam Group Antibiotics Residue in Raw Cow Milk in Sivas Province
by: Nazlı Ercan, et al.
Published: (2022-12-01)

Beta-lactam antibiotics use in intensive care units - the pathophysiological, pharmacokinetic, pharmacodynamic and pharmacoeconomic approach
by: Perić Aneta, et al.
Published: (2015-01-01)

Clinic study of the treatment of hemodialysis combined with hemoperfusion in hemodialysis patients with beta-lactam antibiotics encephalopathy
by: LI Xin-lun, et al.
Published: (2015-01-01)

Development of a UHPLC-UV/Vis Method for Simultaneously Determining Six Beta-Lactam Antibiotics in Plasma: A Tool for the Clinical Implementation of Therapeutic Monitoring of Beta-Lactams
by: Iria Varela-Rey, et al.
Published: (2025-06-01)

Beta-lactam antibiotics as reserve medications for the treatment of drug-resistant tuberculosis
by: G. N. Mozhokina, et al.
Published: (2021-08-01)

Synthesis, characterization, and biological activity using computational study of synthesized monocyclic β-lactam ligands
by: Shweta Shweta, et al.
Published: (2025-06-01)

Impact of Timing of Beta-Lactam Therapeutic Drug Monitoring and Therapy Adjustment in Critically Ill Patients
by: Mohammad H. Alshaer, et al.
Published: (2025-05-01)

β-lactam antibiotics induce metabolic perturbations linked to ROS generation leads to bacterial impairment
by: Dongyang Ye, et al.
Published: (2024-12-01)

Cefotaxime/Sulbactam: an Important Addition to the Arsenal of Inhibitor-Protected Beta-Lactam Antibiotics
by: S. V. Yakovlev, et al.
Published: (2020-05-01)

Selective evolution of methanogenic communities by β-lactam antibiotics promotes methane production
by: Yuting Zhe, et al.
Published: (2025-06-01)

<i>N</i>-Organothio β-Lactams Offer New Opportunities for Controlling Pathogenic Bacteria
by: Edward Turos
Published: (2025-06-01)

Associations between TLRs 2 and 4, and β-lactam antibiotics in COPD patients complicated with pulmonary infections
by: Yunchen Lou, et al.
Published: (2024-06-01)

Deficiency in peptidoglycan recycling promotes β-lactam sensitivity in Caulobacter crescentus
by: Malvika Modi, et al.
Published: (2025-04-01)