Neurotensin induces sustainable activation of the ErbB–ERK1/2 pathway, which is required for developmental competence of oocytes in mice

Neurotensin induces sustainable activation of the ErbB–ERK1/2 pathway, which is required for developmental competence of oocytes in mice

Abstract Purpose LH induces the expression of EGF‐like factors and their shedding enzyme (ADAM17) in granulosa cells (GCs), which is essential for ovulation via activation of the ErbB–ERK1/2 pathway in cumulus cells (CCs). Neurotensin (NTS) is reported as a novel regulator of ovulation, whereas the...

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Bibliographic Details
Main Authors: Asako Okamoto, Tomoya Nakanishi, Shingo Tonai, Masayuki Shimada, Yasuhisa Yamashita
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Reproductive Medicine and Biology
Subjects:
neurotensin
ERK1/2
cumulus cells
granulosa cells
oocyte maturation
Online Access:https://doi.org/10.1002/rmb2.12571
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https://doi.org/10.1002/rmb2.12571

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