A novel small molecule Enpp1 inhibitor improves tumor control following radiation therapy by targeting stromal Enpp1 expression

A novel small molecule Enpp1 inhibitor improves tumor control following radiation therapy by targeting stromal Enpp1 expression

Abstract The uniqueness in each person’s cancer cells and variation in immune infiltrates means that each tumor represents a unique problem, but therapeutic targets can be found among their shared features. Radiation therapy alters the interaction between the cancer cells and the stroma through rele...

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Main Authors: Jason R Baird, Alejandro F Alice, Roland Saito, Qingqing Chai, Minhua Han, Cindy Ng, Stephanie Han, Beth Fernandez, Sarah Ledoux, Johannes Grosse, Alan J Korman, Megan Potuznik, Venkatesh Rajamanickam, Brady Bernard, Marka R Crittenden, Michael J Gough
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-80677-8
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https://doi.org/10.1038/s41598-024-80677-8

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