Design, synthesis, and biological evaluation of (E)-2-benzylidene-1-indanones derivatized by bioisosteric replacement of aurones

Design, synthesis, and biological evaluation of (E)-2-benzylidene-1-indanones derivatized by bioisosteric replacement of aurones

Abstract Thymic stromal lymphopoietin (TSLP) is a cytokine derived from epithelial cells and plays an essential role in the onset and activation of Th2-derived allergic inflammatory conditions, including atopic dermatitis. Despite their potential as drug targets, well-defined small molecules that ef...

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Bibliographic Details
Main Authors: Youngshim Lee, Seunghyun Ahn, Euitaek Jung, Dongsoo Koh, Yoongho Lim, Young Han Lee, Soon Young Shin
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:Applied Biological Chemistry
Subjects:
Aurone
Bioisosteric replacement
(E)-2-benzylidene-1-indanones
Thymic stromal lymphopoietin
Mitogen-activated protein kinase
Online Access:https://doi.org/10.1186/s13765-024-00973-9
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https://doi.org/10.1186/s13765-024-00973-9

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