Emerging role of complement system in the induction of neuroinflammation in adenylosuccinate lyase deficiency disorder

Emerging role of complement system in the induction of neuroinflammation in adenylosuccinate lyase deficiency disorder

Adenylosuccinate lyase deficiency disorder (ADSLDD) is an ultra-rare autosomal recessive metabolic condition that leads to severe neurological impairment, with an estimated global prevalence of approximately 0.00125 cases per 100,000 individuals. Clinically, ADSLDD presents in three distinct phenoty...

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Bibliographic Details
Main Authors: Albert Frank Magnusen, Robert James Hopkin, Charles Vorhees, Elizabeth Wilson, Molly Moehlman, Barbara Hallinan, Craig Erickson, Melissa P. DelBello, Luca Marsili, Nicole G. Coufal, Manoj Kumar Pandey
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Genetic defect
Rare disease
Neuroinflammation
Complement activation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354625001498
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