Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation

Episodic transport of protein aggregates achieves a positive size selectivity in aggresome formation

Abstract Eukaryotic cells direct toxic misfolded proteins to various quality control pathways based on their chemical properties and aggregation status. Aggregated proteins are targeted to selective autophagy or specifically sequestered into the “aggresome”, a perinuclear inclusion at the microtubul...

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Main Authors: Rui Fang, Luolan Bai, Bert M. Verheijen, Boyan Li, Kevin Dong, Joao A. Paulo, Mengying Zhou, Yi-Chi Chu, Yuyu Song, Michael Y. Sherman, Steven Gygi, Christine M. Field, Timothy J. Mitchison, Ying Lu
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62751-5
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https://doi.org/10.1038/s41467-025-62751-5

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